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Semin Thromb Hemost 2019; 45(04): 326-333
DOI: 10.1055/s-0039-1687892
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Thrombotic Complications in Gliomas

Alexandra L. Czap
1   Department of Neurology, University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas
,
Ashley Becker
1   Department of Neurology, University of Texas Health Science Center at Houston McGovern Medical School, Houston, Texas
,
Patrick Y. Wen
2   Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
› Author Affiliations
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Publication History

Publication Date:
30 April 2019 (online)

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Abstract

Arterial and venous thromboses are common in glioma patients, both in the perioperative period and throughout the course of the disease. High-grade glioma patients harbor underlying hypercoagulability, which predisposes these high-risk patients with prolonged immobility and neurologic deficits to thrombotic events. Despite the high incidence and recurrent nature of these complications, there is no standardized approach to the management of glioma patients, and many challenges remain. Historically, the perceived risk of intracranial and intratumoral hemorrhage limited the use of anticoagulation, favoring nonpharmacological prophylaxis and treatment. Multiple studies have demonstrated the safety and efficacy of anticoagulation when indicated, with low molecular weight heparin as the preferred short- or long-term treatment. This review will discuss the epidemiology, risk factors, and therapeutic management of both venous and arterial thrombotic complications in glioma.

Keywords

glioma - thromboembolism - deep venous thrombosis - pulmonary embolism - ischemic stroke